Hyperhidrosis surgery is mostly used with aggravated excessive sweat cases. If your pedal or palmar hyperhidrosis is reaching extreme levels, surgery may be an option. Sympathectomy hyperhidrosis surgery treatment is mostly used to treat excessive hand sweating and pedal hyperhidrosis, but it is also successful in combating axillary hyperhidrosis and other forms of the condition.
Hyperhidrosis surgery is rarely used in the neck and face area, because of the scars it leaves. Of course, before you consider hyperhidrosis surgery you should have a look at other medical treatments and antiperspirants that may help you diminish the negative effects of sweating. ETS is one of the most commonly used hyperhidrosis surgery options, together with the similar sympatherctomy sweat treatments. Sympathectomy hyperhidrosis surgery treatment is used for most types of abnormal sweating but quite often the treatment will need the help of antiperspirants or hyperhidrosis medication.
The betabloqueadores block the action hyperhidrosis surgery of catecholamines endogenous (epinephrine (adrenaline) and norepinephrine (noradrenaline) in the detail), in receivers of ß-adrenergic, the part of the nice nervous system that average the "the fight or the flight" the answer.
There are three known types of receiver of beta, appointed ß1, ß2 and ß3. receivers ß1-Adrenergic are located mainly in the heart. The receivers ß2-Adrenergic are located mainly in the lungs, in gastrointestinal tract, in the liver, in the uterus, in smooth muscle vascular, and in skeletal muscle. ß3-receptors is located in fat cells.
medical excessive sweat treatments the antagonism of ß-receiver
The stimulus of receivers ß1 by epinephrine induces a chronotropic and inotropic positive carries out in the heart and enlarges the cardiac velocity of conduction and automaticity. The stimulus of hyperhidrosis surgery ß2 induces the smooth relaxation of muscle (having as a result vasodilation and bronchodilation among others actions), induces trembling in the skeletal muscle, and enlarges glycogenolysis in the liver and skeletal muscle. The stimulus of receivers ß3 induces lipolysis.
The betabloqueadores inhibit these nice actions, epinephrine the middle and normal, but they have the most minimum effect to rest the subjects. That is, they reduce the effect of the excite/physical effort in the rhythm of the heart and the force of the contraction, the enlargement of blood vessels, opening of bronchial tubes, reduces trembling, and the damage of glycogen..
It is therefore betabloqueadores somewhat unexpected that not selective they have an antihypertensive effect, since they appear to cause the vasoconstricción. The antihypertensive mechanism appears to imply: the reduction in the cardiac production (due to negative effects of chronotropic and inotropic), the reduction in the liberation of renin of the kidneys, and a central effect of nervous system to reduce the nice activity.
The effects of Antianginal result of negative effects of chronotropic and inotropic, that diminishes load of work and the cardiac oxygen demands.
The effects of antiarrhythmic of betabloqueadores arise of the nice blockade of nervous system having as a result the depression of the breast node function and conduction of node of atrioventricular, and of atrial prolonged the stubborn periods. Sotalol, particularly, has the additional properties of antiarrhythmic and prolongs the action the potential duration by potassium channel blockade.
medical excessive sweat treatments the Intrinsic activity of sympathomimetic
Some betabloqueadores (for example. oxprenolol and pindolol) exhibits the intrinsic activity of sympathomimetic (ISA). These agents are capable of exercising the activity low page of agonist in the receiver of ß-adrenergic while acting as simultaneously to an antagonist of the place of receiver. These agents, therefore, can be useful in individuals that exhibit bradycardia excessive with the therapy maintained of hyperhidrosis surgery betabloqueador.
The agents with ISA are not utilized the heart attack post-miocardial as they have not been shown to be beneficial. They can be also less troops than other betabloqueadores in the administration of angina and tachyarrhythmia (Rossi, 2006).
medical excessive sweat treatments the antagonism a1-Receptor
Some betabloqueadores (for example. labetalol and carvedilol) the exhibition mixed the antagonism of both ß- and the receivers a1-adrenergic, that provides the additional action of vasodilating of arteriolar.
medical excessive sweat treatments Other effects
The betabloqueadores diminish the nocturnal liberation of melatonin, perhaps justifying in caused dream disturbance part by some agents (Stoschitzky et to the., 1999).
medical excessive sweat treatments the Clinical use
The large differences exist in the farmacología of agents inside the class, thus not all betabloqueadores are utilized for all indications listed down.
The indications for betabloqueadores include:
* The Hypertension
* Mitral Prolapse of Valve
* The Cardiac arrhythmia
* Heart failure congestiva
* The heart attack Miocardial
* Profilaxis of Migraine
* The Symptomatic hyperhidrosis surgery control (the taquicardia, trembling) in the anxiety and the hipertiroidismo
* Essential Trembling
* Phaeochromocytoma, in conjunction with a-blocker
The betabloqueadores have been utilized also in the following conditions:
* Cardiomyopathy of obstruction Hipertrópico
* To Dissect Sharp aneurysm aórtico
* Syndrome of Marfan (the chronic processing with propranolol loosens progression of the enlargement aórtica and its complications)
* The Prevention to bleed of variceal in the hypertension carries
* Possible Mitigation of hyperhidrosis
medical excessive sweat treatments heart failure congestiva
Although betabloqueadores were once contraindicated in the heart failure congestiva, like they have the potential to be got worse the condition, the studies in the end of the nineties showed its positive effects in the morbosidad and the mortality in the heart failure congestiva (Hjalmarson, 2000; Leizorovicz, 2002; Packer, 2002). Bisoprolol, metoprolol of carvedilol and maintained-liberation is indicated specifically as enclosed to the inhibiting uniform of the ACE and the therapy of the diuretic in the heart failure congestiva.
medical excessive sweat treatments the increase of the Anxiety and the performance
Some people, especially musicians, they utilize betabloqueadores to avoid the scare and trembling of the theater during the performance and public hearings. The physiological symptoms of the answer of the fight/fly associated with the anxiety of the performance and the panic (striking heart, cold/humid hands, the respiration enlarged, to sweat, etc.) they are reduced significantly, thus permitting anxious individuals by concentrate on the task in hand.
At present, no betabloqueador is approved for the anxiolytic use by the US FDA. Still, the use of betabloqueadores to fight the physical symptoms of the anxiety are not rare, especially among artists, and there is the studies that confirm their efficacy as anxiolytic. (Schneier 2006)
Since they descend rhythm of the heart and reduce trembling, the betabloqueadores have been utilized for some Olympic marksmen to enlarge the performance, although betabloqueadores are prohibited for the International Olympic Committee hyperhidrosis surgery (IOC).
medical excessive sweat treatments the Adverse effects
The adverse reactions of the drug (ADRs) associated with the use of betabloqueadores includes: the nausea, the diarrhea, the bronchospasm, dyspnoea, the cold extremities, the exacerbation of syndrome of Raynaud, bradycardia, the low blood pressure, the failure of the heart, the block of heart, the fatigue, the sickness, the abnormal vision, the concentration diminished, the hallucinations, the insomnia, the nightmares, the depression, sexual dysfunction, dysfunction and/or erectile modification of metabolism of glucose Lipid. The therapy a1/ß-antagonist mixed is also associated commonly with low blood pressure of orthostatic. The therapy of Carvedilol is associated commonly with edema. (Rossi, 2006)
The central nervous system (CNS) the adverse effects (the hallucinations, the insomnia, the nightmares, the depression) are more common in agents with the largest solubility of lipid, that can cross the barrier of blood-brain in the CNS. Similar, CNS the adverse effects are less common in agents with the largest watery solubility (listed down).
The adverse effects associated with the receiver antagonist activity ß2-adrenergic (bronchospasm, the hyperhidrosis surgery peripheral, the glucose metabolism modification and lipid) are less common with ß1-selective (often called "cardioselective") agents, nevertheless the selectivity of receiver diminishes in higher dose.
A 2007 study (W.J. Elliott, P. Meyer, The Lancet, the January 20, 2007) revealed that diuretic and betabloqueadores utilized for the hypertension they enlarge a risk of patient of the revealing diabetes. Inhibiting of ACE and Blockers of Receiver of Angiotension (ARBs) diminishes really the risk of the diabetes. The clinical guidelines in Great Britain, but not in the United States, the call to avoid diuretics and betabloqueadores as processing of first-lines of the hypertension due to the risk of the diabetes.
medical excessive sweat treatments the Examples of betabloqueadores
Dichloroisoprenaline, the first one betabloqueador.
Dichloroisoprenaline, the first one betabloqueador.
medical excessive sweat treatments Historic
medical excessive sweat treatments NOT Selective agents
medical excessive sweat treatments agents ß1-Selective
medical excessive sweat treatments Mixed hyperhidrosis surgery antagonists a1/ß-adrenergic
medical excessive sweat treatments agents ß2-Selective
* Butoxamine (the weak activity of agonist of an-adrenergic)
medical excessive sweat treatments Relative information
medical excessive sweat treatments the Pharmacological differences
* Agents with the intrinsic action of sympathomimetic (ISA)
Acebutolol OR, carteolol, celiprolol, mepindolol, oxprenolol, pindolol
* Agents with the largest watery solubility
Atenolol OR, celiprolol, nadolol, sotalol
* Agents with membrane the stabilizing activity
Acebutolol OR, betaxolol, pindolol, propranolol
* Agents with the antioxidant effect
medical excessive sweat treatments the differences of the Indication
* Agents indicated specifically for the cardiac arrhythmia
Esmolol OR, sotalol
* Agents indicated specifically for the heart failure congestiva
Bisoprolol OR, carvedilol, metoprolol of maintained-liberation
* Agents indicated specifically for the glaucoma
Betaxolol OR, carteolol, levobunolol, metipranolol, timolol
* Agents indicated specifically for the heart attack miocardial
Atenolol OR, metoprolol, propranolol
* Agents indicated specifically for the profilaxis of migraine
Timolol OR, propranolol
Propranolol is the only hyperhidrosis surgery agent indicated for the control of trembling, variceal carries of hypertension and oesophageal that bleeds, and utilized in conjunction with the therapy of a-blocker in the phaeochromocytoma
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